In January, Signal experienced technical difficulties after rival messaging app Whatsapp announced a controversial change in privacy terms. Read more: Beware! 2 bn Google Chrome users warned of HUGE threat here's how to stay safe The messaging app said in a tweet earlier on Monday, "Signal is currently down, due to a hosting outage affecting parts of our service." Signal did not immediately respond to a request for comment on the regions affected by the outage. Enjoy the rest of the week, everybody!- Signal September 27, 2021 These results indicate that BPTF transduces key prosurvival signals driven by MITF, further supporting its important role in promoting melanoma cell survival and progression.We are fully back up and running at 100%. MITF overexpression resulted in direct transcriptional activation of BPTF, as evidenced by increased luciferase activity driven by the BPTF promoter. Binding of MITF to the BPTF promoter was demonstrated using ChIP analysis.
The suppression of cell growth mediated by MITF silencing was rescued by overexpression of BPTF cDNA. shRNA-mediated down-regulation of MITF in melanoma cells was accompanied by down-regulation of BPTF and BPTF-regulated genes (including BCL2) and resulted in reduced proliferative capacity of melanoma cells.
Overexpression of MITF resulted in up-regulation of BPTF in a panel of melanoma and melanocyte cell lines. Analysis of the BPTF promoter identified a putative MITF-binding site, suggesting that MITF may regulate BPTF expression. Recent studies identified an oncogenic role for the bromodomain plant homeodomain finger transcription factor (BPTF) gene in melanoma progression, in part through activation of BCL2, a canonical target of MITF signaling. Although several downstream targets of MITF action have been identified, the precise mechanisms by which MITF promotes melanocytic tumor progression are incompletely understood. Microphthalmia-associated transcription factor (MITF) plays a critical and complex role in melanocyte transformation.
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